The following section presents the clinical questions that the working group deemed should be addressed in the Clinical Practice Guideline (CPG) according to the type of intervention.

Pharmacological Interventions

Should antiparkinson drugs be used preventively with second generation antipsychotics?

What side effects should be taken into account when administering second generation antipsychotics?

Are there any differences in terms of efficacy between first and second generation antipsychotics?

Are there any differences in terms of efficacy between Consta type antipsychotics and classic depots?

What is the efficacy of maintenance electroconvulsive therapy (ECT)?

Is the use of antidepressants justified in schizophrenia?

What factors are involved in adherence to treatment?

Effects of cannabis on the onset and course of schizophrenia.

Effects of cocaine on the onset and course of schizophrenia.

What antipsychotics have been proven effective at reducing negative symptoms?

Psychosocial Interventions

a) Psychological Interventions

Does specific treatment produce greater benefits than other psychological interventions?

What are the most effective formats for initial treatment?

Are there any advantages to the concomitant or sequential combination of a specific intervention with other psychological interventions?

b) Psychosocial Rehabilitation

Does the specified treatment produce greater benefits than other psychological treatments?

What are the most efficient formats for treatment (for example, group-based or individual treatment)?

Is there any advantage to the concomitant or sequential combination of a specific intervention with other psychological interventions?

What configuration/s most favours and promotes recovery?

What service provision model promotes paid employment?

c) Modalities of care to the community

What does assertive community treatment consist of?

What patient profile is it aimed at?

What types of community-based treatments are available?

What are the differences between the different modalities of care to the community?

Is there any scientific evidence to determine that one type of treatment is superior to another?

What are the outcomes of these treatments?

What is the recommended length of these treatments?